| |
|
|
| Registros recuperados : 5 | |
| 1. |  | LORENZETTI, W. R.; IBELLI, A. M. G.; PEIXOTO, J. de O.; MORES, M. A. Z.; SAVOLDI, I. R.; CARMO, K. B. do; OLIVEIRA, H. C. de; LEDUR, M. C. Identification of endogenous normalizing genes for expression studies in inguinal ring tissue for scrotal hernias in pigs. Plos One, v. 13, n.9, e0204348, 2018.| Biblioteca(s): Embrapa Suínos e Aves. |
|    |
| 2. | | ROMANO, G. de S.; IBELLI, A. M. G.; LORENZETTI, W. R.; WEBER, T.; PEIXOTO, J. de O.; CANTAO, M. E.; MORES, M. A. Z.; MORÉS, N.; PEDROSA, V. B.; COUTINHO. L. L.; LEDUR, M. C. Inguinal ring RNA sequencing reveals downregulation of muscular genes related to scrotal hernia in pigs. Genes, v. 11, n. 117, 2020.| Biblioteca(s): Embrapa Suínos e Aves. |
| |
| 3. | | FERNANDES, L. T.; ONO, R. K.; IBELLI, A. M. G.; LAGOS, E. B.; MORES, M. A. Z.; CANTAO, M. E.; LORENZETTI, W. R.; PEIXOTO, J. de O.; PEDROSA, V. B.; LEDUR, M. C. Novel putative candidate genes associated with umbilical hernia in pigs. In: WORLD CONGRESS ON GENETICS APPLIED TO LIVESTOCK PRODUCTION, 11., 2018, Auckland, New Zealand. Proceedings... Massey University, 2018. Digital Archive.| Biblioteca(s): Embrapa Suínos e Aves. |
|  |
| 4. | | MÜLLER, L. K. F.; PAIANO, D.; GUGEL, J.; LORENZETTI, W. R.; SANTURIO, J. M.; TAVERNARI, F. de C.; GLORIA, E. M. da; BALDISSERA, M. D.; SILVA, A. S. da. Post-weaning piglets fed with different levels of fungal mycotoxins and spray-dried porcine plasma have improved weight gain, feed intake and reduced diarrhea incidence. Microbial Pathogenesis, v. 117, p. 259-264, 2018.| Biblioteca(s): Embrapa Suínos e Aves. |
| |
| 5. | | ROMANO, G. de S.; LORENZETTI, W. R.; IBELLI, A. M. G.; PEIXOTO, J. de O.; MORES, M. A. Z.; SAVOLDI, I. R.; CARMO, K. B. do; LOPES, J. S.; PEDROSA, V. B.; CANTAO, M. E.; COUTINHO, L. L.; LEDUR, M. C. The involvement of muscle-related genes in the occurrence of scrotal hernia in pigs. In: WORLD CONGRESS ON GENETICS APPLIED TO LIVESTOCK PRODUCTION, 11., 2018, Auckland, New Zealand. Proceedings... Massey University, 2018. Digital Archive.| Biblioteca(s): Embrapa Suínos e Aves. |
| |
| Registros recuperados : 5 | |
|
|
|
 | Acesso ao texto completo restrito à biblioteca da Embrapa Suínos e Aves. Para informações adicionais entre em contato com cnpsa.biblioteca@embrapa.br. |
Registro Completo
|
Biblioteca(s): |
Embrapa Suínos e Aves. |
|
Data corrente: |
03/11/2020 |
|
Data da última atualização: |
03/11/2020 |
|
Tipo da produção científica: |
Artigo em Periódico Indexado |
|
Circulação/Nível: |
A - 2 |
|
Autoria: |
ROMANO, G. de S.; IBELLI, A. M. G.; LORENZETTI, W. R.; WEBER, T.; PEIXOTO, J. de O.; CANTAO, M. E.; MORES, M. A. Z.; MORÉS, N.; PEDROSA, V. B.; COUTINHO. L. L.; LEDUR, M. C. |
|
Afiliação: |
GABRIELI DE SOUZA ROMANO, UFBA; ADRIANA MERCIA GUARATINI IBELLI, CNPSA; WILLIAN RAPHAEL LORENZETTI, UNICENTRO; TOMÁS WEBER, BRF; JANE DE OLIVEIRA PEIXOTO, CNPSA; MAURICIO EGIDIO CANTAO, CNPSA; MARCOS ANTONIO ZANELLA MORES, CNPSA; NELSON MORÉS, CNPSA; VICTOR BRENO PEDROSA, UEPG; LUIZ LEHMANN COUTINHO, ESALQ; MONICA CORREA LEDUR, CNPSA. |
|
Título: |
Inguinal ring RNA sequencing reveals downregulation of muscular genes related to scrotal hernia in pigs. |
|
Ano de publicação: |
2020 |
|
Fonte/Imprenta: |
Genes, v. 11, n. 117, 2020. |
|
DOI: |
https://doi.org/10.3390/genes11020117 |
|
Idioma: |
Inglês |
|
Conteúdo: |
Abstract: Scrotal hernias (SH) are common congenital defects in commercial pigs, characterized by the presence of abdominal contents in the scrotal sac, leading to considerable production and animal welfare losses. Since the etiology of SH remains obscure, we aimed to identify the biological and genetic mechanisms involved in its occurrence through the whole transcriptome analysis of SH affected and unaffected pigs? inguinal rings. From the 22,452 genes annotated in the pig reference genome, 13,498 were expressed in the inguinal canal tissue. Of those, 703 genes were differentially expressed (DE, FDR < 0.05) between the two groups analyzed being, respectively, 209 genes upregulated and 494 downregulated in the SH-affected group. Thirty-seven significantly overrepresented GO terms related to SH were enriched, and the most relevant biological processes were muscular system, cell differentiation, sarcome reorganization, and myofibril assembly. The calcium signaling, hypertrophic cardiomyopathy, dilated cardiomyopathy, and cardiac muscle contraction were the major pathways possibly involved in the occurrence of the scrotal hernias. The expression profile of the DE genes was associated with the reduction of smooth muscle dierentiation, followed by low calcium content in the cell, which could lead to a decreased apoptosis ratio and diminished muscle contraction of the inguinal canal region. We have demonstrated that genes involved with musculature are closely linked to the physiological imbalance predisposing to scrotal hernia. According to our study, the genes MYBPC1, BOK, SLC25A4, SLC8A3, DES, TPM2, MAP1CL3C, and FGF1 were considered strong candidates for future evaluation. MenosAbstract: Scrotal hernias (SH) are common congenital defects in commercial pigs, characterized by the presence of abdominal contents in the scrotal sac, leading to considerable production and animal welfare losses. Since the etiology of SH remains obscure, we aimed to identify the biological and genetic mechanisms involved in its occurrence through the whole transcriptome analysis of SH affected and unaffected pigs? inguinal rings. From the 22,452 genes annotated in the pig reference genome, 13,498 were expressed in the inguinal canal tissue. Of those, 703 genes were differentially expressed (DE, FDR < 0.05) between the two groups analyzed being, respectively, 209 genes upregulated and 494 downregulated in the SH-affected group. Thirty-seven significantly overrepresented GO terms related to SH were enriched, and the most relevant biological processes were muscular system, cell differentiation, sarcome reorganization, and myofibril assembly. The calcium signaling, hypertrophic cardiomyopathy, dilated cardiomyopathy, and cardiac muscle contraction were the major pathways possibly involved in the occurrence of the scrotal hernias. The expression profile of the DE genes was associated with the reduction of smooth muscle dierentiation, followed by low calcium content in the cell, which could lead to a decreased apoptosis ratio and diminished muscle contraction of the inguinal canal region. We have demonstrated that genes involved with musculature are closely linked to the physiol... Mostrar Tudo |
|
Palavras-Chave: |
Congenital disease; Differentially expressed genes; Doença congênita; Genes expressos diferencialmente; Hérnia escrotal; Sequenciamento do RNA; Transcriptoma. |
|
Thesagro: |
Genética Animal; Porco; Suíno. |
|
Thesaurus NAL: |
Animal genetics; Swine; Swine diseases; Transcriptome. |
|
Categoria do assunto: |
-- |
|
Marc: |
LEADER 02908naa a2200421 a 4500
001 2126201
005 2020-11-03
008 2020 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.3390/genes11020117$2DOI
100 1 $aROMANO, G. de S.
245 $aInguinal ring RNA sequencing reveals downregulation of muscular genes related to scrotal hernia in pigs.$h[electronic resource]
260 $c2020
520 $aAbstract: Scrotal hernias (SH) are common congenital defects in commercial pigs, characterized by the presence of abdominal contents in the scrotal sac, leading to considerable production and animal welfare losses. Since the etiology of SH remains obscure, we aimed to identify the biological and genetic mechanisms involved in its occurrence through the whole transcriptome analysis of SH affected and unaffected pigs? inguinal rings. From the 22,452 genes annotated in the pig reference genome, 13,498 were expressed in the inguinal canal tissue. Of those, 703 genes were differentially expressed (DE, FDR < 0.05) between the two groups analyzed being, respectively, 209 genes upregulated and 494 downregulated in the SH-affected group. Thirty-seven significantly overrepresented GO terms related to SH were enriched, and the most relevant biological processes were muscular system, cell differentiation, sarcome reorganization, and myofibril assembly. The calcium signaling, hypertrophic cardiomyopathy, dilated cardiomyopathy, and cardiac muscle contraction were the major pathways possibly involved in the occurrence of the scrotal hernias. The expression profile of the DE genes was associated with the reduction of smooth muscle dierentiation, followed by low calcium content in the cell, which could lead to a decreased apoptosis ratio and diminished muscle contraction of the inguinal canal region. We have demonstrated that genes involved with musculature are closely linked to the physiological imbalance predisposing to scrotal hernia. According to our study, the genes MYBPC1, BOK, SLC25A4, SLC8A3, DES, TPM2, MAP1CL3C, and FGF1 were considered strong candidates for future evaluation.
650 $aAnimal genetics
650 $aSwine
650 $aSwine diseases
650 $aTranscriptome
650 $aGenética Animal
650 $aPorco
650 $aSuíno
653 $aCongenital disease
653 $aDifferentially expressed genes
653 $aDoença congênita
653 $aGenes expressos diferencialmente
653 $aHérnia escrotal
653 $aSequenciamento do RNA
653 $aTranscriptoma
700 1 $aIBELLI, A. M. G.
700 1 $aLORENZETTI, W. R.
700 1 $aWEBER, T.
700 1 $aPEIXOTO, J. de O.
700 1 $aCANTAO, M. E.
700 1 $aMORES, M. A. Z.
700 1 $aMORÉS, N.
700 1 $aPEDROSA, V. B.
700 1 $aCOUTINHO. L. L.
700 1 $aLEDUR, M. C.
773 $tGenes$gv. 11, n. 117, 2020.
Download
Esconder MarcMostrar Marc Completo |
|
Registro original: |
Embrapa Suínos e Aves (CNPSA) |
|
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
Fechar
|
| Nenhum registro encontrado para a expressão de busca informada. |
|
|
